I think that ANY marks should be thoroughly washed out of the fabric, not just minimized so that they don't show at the moment. Personally, I think that wetting the marks made with the blue wash out pens just makes the chemicals soak into the batting to reappear at a later date!!
What has worked for me has been to soak any quilt that has been marked with any kind of marker in a washer full of cool/cold water for about 15 minutes with NO SOAP.
I drain that water out of the machine, then launder the quilt with a mild soap (I like Orvus Paste) in a regular or gentle cycle. That way I feel like the chemicals are removed from the fibers.
I get Orvus at the local farmer's co-op!
http://www.farmandfleet.com/products/062513-orvus_paste_soap.html
It comes in a 7 pound jug for $21.49
or a smaller amount:
http://www.amazon.com/Quilters-Rule-Quilt-Soap-Orvus/dp/B000BQLJIU
8 oz for $13.69