I would try samples to see what you like the best. Sometimes, with little tiny pieces, using a 100 wt silk thread and a tiny needle enables better stitching. What's the end use of the quilt? Do you want the expense of silk thread? Will it be shown or for your own use. Will people see it up close? Stand back 6 feet and look at your samples. They don't have to be perfection if not in a show. Repeating some advice of Robin Gausbeck, award winning appliquer, TQS member
, it helps to put a magnifier on the machine, too.