I've applied this with basting spray... it held it down better than just pinning. I agree with Teri, pinning (or spray-basting) it to just a couple blocks at a time is easier. The more you handle it, the more it wrinkles and starts peeling off. (if using a frame quilting machine, this probably wouldn't be an issue).
The main problem I had with the Golden Threads paper is that tiny bits of it end up stuck under your stitches after you tear it away. I tried washing the quilt, but this didn't get rid of the bits, so I picked them out with tweezers while watching TV. Depending on your fabric color/pattern, these bits might not be noticeable and could safely be ignored.
I tried once using a water-soluble embroidery stablizer for this purpose, but it was too stretchy and kept rucking up under the presser foot. I wonder if one of the water-soluble foundation papers would work for quilting designs. Has anyone tried this?