Hi Sandra -
As Marianne says, it depends on the look you want and the technique you are using. However, hand applique is generally done on a single layer of fabric. Depending on the quilt pattern, you may have several applique blocks which you then piece together into the quilt top. Then, layer, baste and quilt. That's the traditional and most common method, and probably what you would want to do as a start. It's a lot easier to hand applique through a single layer of fabric than through a quilt. This is also the method shown in the latest show. There will probably be an applique project added to the TQS projects for this show, so that might be a good thing to start with. I would guess it would be the little block that she worked on in the show. Have fun and be sure to show us what you do!! And let us know whenever you have questions.