I use the horizontal lines on the cutting mat to make as many folds as necessary to get the length down to less than 24", which I can cut with my long ruler.
When trimming selvage edges to piece large pieces of backing fabric for a large quilt, I will carefully line up the selvage edges as I fold them, and then line the folds up with the vertical lines on the cutting mat, and use the horizontal lines on the mat to trim the selvage by moving the ruler several times to cut the length of the fabric.
I do have a large (30" s 60") cutting mat, so it's easier than using a small portable mat.
Hope this info isn't too confusing!