Ok, here is my two cents, hehe.
I applique a LOT! If you go to my profile and look at pictures, you will see 2 quilts, one an iris quilt I made about 15 years ago and a hummingbird quilt, it has a beige background. Both of these were appliqued and I currently have 2 more that I haven't posted. I use VERY sharp small KAI scissors, and I also have a small Gingher pair that I use. I feel the important part is very sharp. The KAI scissors was in a set that I actually won when at a TQS taping several years ago and I LOVE them. I use the small scissors even for large pieces so I can be accurate. I know the kind you are looking at has serrated edges, but I am sure they work fine too. Before you purchase them, try the scissors you have and see if they work for you.
Ok, I also just use regular tweezers.
As far as left handed, I can't help you there. Ok, now I also do David Taylor method of preparing my applique. I trace the pattern onto freezer paper and cut that out then iron it onto the back side of the fabric, cut around a scant 1/4, clip where needed. I then use spray starch into a small jar and let it liquify and add a little water and paint on the selvage of the piece with the starch and iron it over. I leave the freezer paper in until I am ready to apply it to the quilt. I also use Roxanne's Glue Baste It to keep them on the quilt.
Hope this helps.
Sharon in warm Colorado