Not a definitive answer because I'm right-handed... however, I tried the Apliquick scissors with my left hand and they did not cut. I tried my Karen Kay Buckley scissors with my left hand (I usually use them with the right) and they did cut through the fabric with scissors in the left hand. So, I suspect the Apliquick scissors are designed for right-handed users.
I have both larger and small Apliquick scissors--easy to hold, serrated edge is nice too. Truth be told, you don't need the extra holes to hold the scissors the way it is demonstrated in the Apliquick demo: you can hold any pair of scissors that way (in fact, that is the way I first learned to hold scissors). I'm glad I purchased them and I do use them; in terms of the serrated blade, for me, they are comparable to my Karen Kay Buckley scissors.
I have the tweezers and really like them because you have a larger flat surface on the tweezers to hold with your thumb and finger (better leverage as you hold the fabric) and I also like the fact that the tweezers are much shorter than a regular pair of tweezers: they basically stay within the palm of your hand when you use them. Those two features make it much more comfortable for me to hold the tweezers.