I just did a full sized quilt, was the 2nd thing I have quilted on my home machine. Some things I learned that helped me....
--definitely to the stitch in the ditch like they say. That helped so much, even though it was slow and with not much to show for it, I didn't have to worry about the quilt shifting around after that.
--I used just simple straight line quilting for the most part, with the walking foot, which helped a ton. I used a decorative stitch to add visual interest instead of "just" straight lines.
--play around with how to support the quilt -- books, etc. to make the surface on the left and back even with the machine, so the weight of the quilt is not sagging down and pulling the quilt as it goes through the machine. But then play around with how to hold the quilt, how to smush up the part that goes in the neck -- will you roll it? Accordion it? Hand under the excess? hand holding the roll? The excess to the left, over your shoulder? hanging down onto the floor? Over your arm? It took me a few passes and trying different ways to figure out/find the best way of holding & manuevering the quilt that was most comfortable for me. Even things like when the excess is all in your lap, and as you move the quilt through, don't forget to scoot your chair in closer as you gain more room.
--Don't be afraid to do free motion stuff in small sections. I did very basic free motion (I was outlining a comic strip drawn by my son, so just straight lines but in different directions) in the central blocks. Once I got the hang of moving that heavy quilt it was easy and fun, and did feel like it went faster because it was visible progress.
--I did read something on a blog, but haven't tried it yet, where she makes the full quilt top and back, but puts the batting in as thirds since you have to usually piece the batting anyway. So, say you are doing all horizontal straight line quilting; she cuts a batting long enough to go the width of the quilt, puts that (and bastes it in) in the middle horizontal section of the quilt, quilts all that (first the stitch in the ditch, then the quilting) and *then* puts the next piece of batting; she secures the batting to each other with that batting tape/sewing thingy and then bastes the top/bottom to that section of batting and then quilts. And so on until done. This way, the excess quilt is just top/back, not batting layer, so much less bulk and weight.
I haven't done it that way yet, but plan to on my next quilt. here is a link with helpful info, including explanation on the quilting in thirds bit; I can't seem to find the blog I read which had pictures, but this explains it very well.
http://www.quiltuniversity.com/batting_a_quilt.htm
Have fun!