EQ 6 will print applique patterns in several pages, overlapping the larger pieces on to two or more pages. You can also move the pieces around for better placement on the page. However, designing applique has its limitations.
However, for real flexibility, I use CorelDraw X5 (older versions do the same) as it will print a large pattern on multiple pages. You can also design anything with this software. Right now, I am working on a huge (7' x 9') wall hanging that has hundreds of pieces. I drew it to scale in CorelDraw, and even though it is on a normal size piece of paper on screen, I adjusted the scale so my the rulers say it is 10x that size. The biggest pieces are about 14" wide. Some small ones are only 1/2" wide. I've printed nearly all of the pieces by using the multiple page feature. It wanted to print them at the normal size (as if the scale was 8.5 x 11) but the printer window allows me to increase the scale or size of what I want to print. The "print preview" feature also allows me to move the pieces to best fit on my paper. If the selection I am printing is bigger than 8.5" x 11" I can print part of the selection, then move it to include what was missed and print again, without closing the print preview window. I love CorelDraw!