As Ann said, red and black bleeds easily!...but do not forget green too
Red and green are the colors which needs more pigments to get the colors. Black will bleed because it has red/green in it :shock:
If you prewash your fabric or your finished quilttop...use vinegar (for hand-and machine washing), the vinegar will fixate the colors!
I have to admit, I do not prewash my fabric, but after its done.With some vinegar (white) added I have never ruined any quilt