I am in the process of quilting a wool quilt. I used wool batting and cotton backing (after much thought about whether to use flannel or fleece or what - in the end I decided on wide-backed cotton as I reckoned it would be the most stable.) I used a quarter inch seam allowance which was fine and steam pressed the seams open as this made it easier to join the squares. Here's a photo of how I pinned then together. I made sure the pin was joining both front and back exactly in the seam allowance and this made them match up perfectly.
The only problem is that, for me anyway, it was too difficult to try to quilt in on my domestic machine. I am in the process of hand quilting mine with big stitches. Here's a photo -
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Good luck with whatever you end up doing.
Rita.