I think that a lot of the fear of using a domestic machine comes from the thought of putting a whole quilt through the harp area. When you see a photo of a large quilt you see all that surface area. This 2011 BOM measures 84" square:
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First of all...you only have to get one half of that area under through the harp at one time, and that is just to quilt the center part of the quilt. After that, it's always less! Considering that, you only need to deal with 42". Does that sound more manageable?
Now...look at this. I can gently bunch up the completed quilt to fit in the circle formed with my thumb and middle finger!! Yes....this is already quilted, and a little more compact than three unquilted layers, but it's still definitely manageable!
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When quilting on a domestic machine, you only need to be concerned with the area of the quilt that fits between your two flat hands. If you have trouble managing that, you might consider using one of Sharon Schamber's Halo. I find it to be a huge help when quilting on a domestic machine. Here is a link to a video showing how it works:
http://www.youtube.com/watch?v=SpmMYIDCrZw