I use 505 basting spray all the time, as do many in our group. You should only spray the batting, not the fabric, as the fabric absorbs it too much. For medium to large quilts I will pin or tack around the outside edge just to make sure it doesn't peel back with all the handling. I've used it for both hand and machine quilting projects and LOVE it

Gently ironing with your iron set to steam will reactivate the sticky of the basting spray.

I have been spray basting for 12 years now, ever since the sprays first became common and I use them exclusively for all my quilts and no pins at all. In my opinion they hold every square inch of the quilt to the batting & back, something that isn't true for either pin or thread basting. Pins also add a considerable amount of weight to a quilt sandwich. I use Sullivan's spray but I have also used 505 with good results. Like any other product we add to our quilts, i.e. fusible web, paint,starch, sizing, etc., you may have better results if your fabric was washed before making the quilt. The factory sizing can act like teflon in some circumstances. Yes, spray adhesive is a chemical you are adding to your quilt, but all the fabric we buy and all the other products we use are loaded with chemicals and it seems arbitrary to start objecting to spray baste. All the chemicals in fabric is one good reason to pre-wash all your fabric. I do iron the back smooth after I get the whole thing basted, it seems to help adhere the adhesive better. It is easy to reposition during this process and afterward if need be.
I am confident that the adhesive does wash out, not only from my own testing on quilts but the results from washing the old sheet I sometimes use when I need to spray a top or backing on the garage floor when the weather is bad. I am adamant about spraying outside, no one needs adhesive in their lungs or on their furnishings. I spray the wrong side of the back, bring it in and pin it to the floor or up on my design wall. Smooth the batting over, then spray the wrong side of the top outside and bring it in and place it over the batting. I dislike spraying the batting because the loft of the batting seems to require more spray to hold and that can result in gummy needles.
I work for Possibilities and probably quilt 1-2 quilts a week at work, all spray basted and then come home to my own quilting, so I do have a good deal of experience with spray!

I've used both Sullivan's and June Tailor basting sprays with very good results. I've never had a problem with having to re-spray, but I'm very careful to smooth out each layer VERY firmly, and I use pins about every 10 to 12 inches or so, leaving them in until I quilt in that area. The first couple of times I used it (several years ago) the needle gummed up a bit, but haven't had any trouble with that recently. Using some Sewer's Aid on the needle may also help.

I used the 505 to baste my 86" square 2009 Sue Garman BOM. It worked great. I basted on my folding table, starting in the middle and doing a section at a time - got the whole backing smooth, turned it over, and then added the quilt top. I didn't have to respray at all.

I have all of PATSY THOMPSONs DVDs on machine quilting and love them. I do not use the sprays... to much chemicals for me... if I can not pronounce it ... it does not get used in my house.... too many allergies and asthma... I do not want to expose my 2 year old grandson.

I use SHARON SCHAMBERS method of basing using HERRRING BONE STITCHES.... works great for me.

I am making a sofa throw using her patterns/ teaching from the DVD and the putting them together using the FUN AND DONE method. ( Fun and Done is a revival of quilt as you go method from the late 1800s-early 1900 type of quilting.

Just watched the first installment of the wonderful Patsy Thompson video on machine quilting. (Thanks, so much TQS.) I loved her tip about spray basting using a "basting wall", but wondered what kind of success everyone has had with spray basting anything larger than a wall hanging.

I've tried spray basting on a child's quilt, but found that the adhesive didn't really hold over the hours it took to do the machine quilting. I ended up having to respray quite often to finish the job. I wasn't using the 505 Spray Basting that she mentioned. Did that make the difference?